| Date | VT Rank | Opponent | Result | TV | Location |
|---|---|---|---|---|---|
| Sat., Sep 30, 1905 | Roanoke College | W, 86-0 | Blacksburg, Va. | ||
| Fri., Oct 6, 1905 | Cumberland (Tenn.) | W, 12-0 | Blacksburg, Va. | ||
| Sat., Oct 14, 1905 | at Army | W, 16-6 | West Point, N.Y. | ||
| Sat., Oct 21, 1905 | Gallaudet | W, 56-0 | Blacksburg, Va. | ||
| Sat., Oct 28, 1905 | vs. North Carolina | W, 35-6 | Richmond, Va. | ||
| Sat., Nov 4, 1905 | at Virginia | W, 11-0 | Charlottesville, Va. | ||
| Sat., Nov 11, 1905 | Washington & Lee | W, 15-0 | Blacksburg, Va. | ||
| Sat., Nov 18, 1905 | vs. South Carolina | W, 34-0 | Roanoke, Va. | ||
| Sat., Nov 25, 1905 | at Navy | L, 6-12 | Annapolis, Md. | ||
| Thu., Nov 30, 1905 | vs. VMI | W, 34-0 | Richmond, Va. |
| Overall: 9-1 Conference: 0-0 Home: 4-0 Away: 2-1 Neutral: 3-0 |
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