| Date | VT Rank | Opponent | Result | TV | Location |
|---|---|---|---|---|---|
| Sat., Oct 1, 1910 | Hampden-Sydney | W, 18-0 | Blacksburg, Va. | ||
| Wed., Oct 5, 1910 | Davidson | W, 16-6 | Blacksburg, Va. | ||
| Sat., Oct 15, 1910 | Western Maryland | W, 13-0 | Blacksburg, Va. | ||
| Sat., Oct 22, 1910 | at Navy | L, 0-3 | Annapolis, Md. | ||
| Sat., Oct 29, 1910 | vs. Washington & Lee | W, 23-0 | Roanoke, Va. | ||
| Sat., Nov 5, 1910 | vs. North Carolina | W, 20-0 | Richmond, Va. | ||
| Sat., Nov 12, 1910 | vs. George Washington | W, 16-5 | Lynchburg, Va. | ||
| Thu., Nov 24, 1910 | vs. NC State | L, 3-5 | Norfolk, Va. |
| Overall: 6-2 Conference: 0-0 Home: 3-0 Away: 0-1 Neutral: 3-1 |
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