| Date | VT Rank | Opponent | Result | TV | Location |
|---|---|---|---|---|---|
| Sat., Sep 12, 1981 | Richmond | W, 28-12 | Blacksburg, Va. | ||
| Sat., Sep 19, 1981 | William & Mary | W, 47-3 | Blacksburg, Va. | ||
| Sat., Sep 26, 1981 | Wake Forest | W, 30-14 | Blacksburg, Va. | ||
| Sat., Oct 3, 1981 | Memphis | W, 17-13 | Blacksburg, Va. | ||
| Sat., Oct 10, 1981 | at Duke | L, 7-14 | Durham, N.C. | ||
| Sat., Oct 17, 1981 | at West Virginia | L, 6-27 | Morgantown, W.Va. | ||
| Homecoming | |||||
| Sat., Oct 24, 1981 | Appalachian State | W, 34-12 | Blacksburg, Va. | ||
| Sat., Oct 31, 1981 | at Kentucky | W, 29-3 | Lexington, Ky. | ||
| Sat., Nov 14, 1981 | at #12 Miami | L, 14-21 | Miami, Fla. | ||
| Sat., Nov 21, 1981 | VMI | L, 0-6 | ABC (regional) | Blacksburg, Va. | |
| Sat., Nov 28, 1981 | at Virginia | W, 20-3 | Charlottesville, Va. | ||
| Overall: 7-4 Conference: 0-0 Home: 5-1 Away: 2-3 Neutral: 0-0 |
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