| Date | VT Rank | Opponent | Result | TV | Location |
|---|---|---|---|---|---|
| Sat., Sep 2, 2006 | #17 | Northeastern | W, 38-0 | ESPN360 | Lane Stadium |
| Sat., Sep 9, 2006 | #16 | at North Carolina * | W, 35-10 | ESPN (national) | Chapel Hill, N.C. |
| Sat., Sep 16, 2006 | #14 | Duke * | W, 36-0 | LFS / Raycom | Lane Stadium |
| Sat., Sep 23, 2006 | #11 | Cincinnati | W, 29-13 | ESPNU (national) | Lane Stadium |
| Orange Effect | |||||
| Sat., Sep 30, 2006 | #11 | #24 Georgia Tech * | L, 27-38 | ABC (regional) | Lane Stadium |
| Thu., Oct 12, 2006 | #22 | at Boston College * | L, 3-22 | ESPN (national) | Chestnut Hill, Mass. |
| Homecoming | |||||
| Sat., Oct 21, 2006 | Southern Miss | W, 36-6 | ESPNU (national) | Lane Stadium | |
| Maroon Effect & Hokies For The Hungry | |||||
| Thu., Oct 26, 2006 | #10 Clemson * | W, 24-7 | ESPN (national) | Lane Stadium | |
| Sat., Nov 4, 2006 | #23 | at Miami * | W, 17-10 | ABC | Miami, Fla. |
| Hall Of Fame | |||||
| Sat., Nov 11, 2006 | #20 | Kent State | W, 23-0 | ESPNU | Lane Stadium |
| Sat., Nov 18, 2006 | #19 | at #14 Wake Forest * | W, 27-6 | ESPN2 | Winston-Salem, N.C. |
| Sat., Nov 25, 2006 | #17 | Virginia * | W, 17-0 | LFS / Raycom | Lane Stadium |
| Chick-fil-A Bowl | |||||
| Sat., Dec 30, 2006 | #14 | vs. Georgia | L, 24-31 | ESPN (national) | Atlanta, Ga. |
| Overall: 10-3 Conference: 6-2 Home: 7-1 Away: 3-1 Neutral: 0-1 Season Stats: View | Head Coach: Frank Beamer Preseason Ranking: 17 Final Ranking: 19 |
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